Can Centaurs and Talking Pigs Be Far Behind?

Nobel laureate and famed geneticist Sydney Brenner once delivered a somewhat tongue-in-cheek lecture to students at Cambridge University about how to nonsurgically create a centaur. He concluded that one day soon it might be possible to create such a six-limbed vertebrate. Mermaids and other mythical hybrids might be on the way, too, as well as human-dog drudges trained to cook omelets and happily perform useful tasks around the house, like changing the light bulbs. This day has not yet arrived, but it may be inching closer with a recent amendment to a bill in the British Parliament that would legalize human hybrids for research. This legislation, offered by the British Department of Health, is a U-turn from government ministers who said last December that they supported a ban on creating chimeras. Since then, a vigorous and sometimes contentious debate has raged in the United Kingdom between supporters of a ban--some religious, some not--and the scientific community, led by Ian Wilmut (Dolly the sheep) and others who insist that a ban would stifle research into stem-cell treatments. On March 28, a lengthy report by the Science and Technology Committee in the House of Commons endorsed chimerical research as part of the legislation reauthorizing the Human Fertilization and Embryology Act of 1990. Wilmut and the other United Kingdom scientists are not interested in making mermaids--or mermen, either. They want to use animal eggs to grow human stem cells by cleaning out 99.9 percent of the animal materials from the eggs and injecting them with human DNA. These hybrids would provide a solution to the severe shortage of pure human eggs needed for embryonic stem-cell research, which now depends on human volunteers to provide eggs.